Human disease models development
Human disease models in drug development
Author: Anna Loewa, James J. Feng, Sarah Hedtrich
Abstract: Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process. Major drivers for this transition are the limitations of animal models, which, despite remain ing the gold standard in basic and preclinical research, suffer from interspecies differences and poor prediction of human physiological and pathological conditions. To bridge this translational gap, bioengineered human disease models with high clinical mimicry are being developed. In this Review, we discuss preclinical and clinical studies that benefited from these models, focusing on organoids, bioengineered tissue models and organsonchips. Furthermore, we provide a highlevel design framework to facilitate clinical translation and accelerate drug development using bioengineered human disease models.
